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KMID : 0379520120280010025
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한국독성학회지
2012 Volume.28 No. 1 p.25 ~ p.31
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Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles
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Kwon Jung-Taek
Arash Minai-Tehrani
Hwang Soon-Kyung
Kim Ji-Eun
Shin Ji-Young
Yu Kyeong-Nam
Chang Seung-Hee
Kim Dae-Seong
Kwon Yong-Taek
Choi In-Ja
Cheong Yun-Hee
Kim Jun-Sung
Cho Myung-Haing
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Abstract
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The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 nm in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs in mice were evaluated using a nose-only exposure chamber (NOEC) system. Bronchoalveolar lavage (BAL) fluid analysis, Western blotting, histopathological changes, and silver burdens in various organs were determined in mice. Mice were exposed to MSNPs for 6 hrs. The mean concentration, total surface area, volume and mass concentrations in the NOEC were maintained at 1.93 × 107 particles/cm3, 1.09 × 1010 nm2/cm3, 2.72 × 1011 nm3/cm3, and 2854.62 μg/m3, respectively. Inhalation of MSPNs caused mild pulmonary toxicity with distribution of silver in various organs but the silver burdens decreased rapidly at 24-hrs post-exposure in the lung. Furthermore, inhaled MSNPs induced activation of mitogen-activated protein kinase (MAPK) signaling in the lung. In summary, single inhaled MSNPs caused mild pulmonary toxicity, which was associated with activated MAPK signaling. Taken together, our results suggest that the inhalation toxicity of MSNPs should be carefully considered at the molecular level.
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KEYWORD
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Inhalation, Silver nanoparticles, Pulmonary toxicity, Distribution, Mitogen-activated protein kinase
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